Catalytic Asymmetric Synthesis of Chiral Allylic Esters
- 12 February 2005
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 127 (9), 2866-2867
- https://doi.org/10.1021/ja0425583
Abstract
Trichloroacetimidate derivatives of prochiral (Z)-2-alken-1-ols react at room temperature with carboxylic acids to give chiral 3-acyloxy-1-alkenes in high enantiopurity in the presence of di-μ-acetatobis[(η5-(S)-(pR)-2-(2‘-(4‘-methylethyl)oxazolinyl)cyclopentadienyl,1-C,3‘-N)(η4-tetraphenylcyclobutadiene)cobalt]dipalladium (COP-OAc) or its enantiomer. This reaction has broad scope, proceeds with predictable high stereoinduction, is accomplished at room temperature using high substrate concentrations and low catalyst loadings, and likely proceeds by a novel mechanism.This publication has 41 references indexed in Scilit:
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