The immunobiology ofvitamin D: William F.C. Rigby

Abstract

Vitamin D compounds are important components of the endocrine system — being largely responsible for calcium metabolism. But the most active member of the group (calcitriol)] also interacts extensively with the immune system, as William Rigby reviews, here. While an immunological role has not yet been definitively identified, calcitriol appears to act at sites of iflammation to limit T-cell activation and activate macrophage cytotoxicity.