Hormone replacement therapy: current controversies
Open Access
- 28 February 2003
- journal article
- review article
- Published by Wiley in Clinical Endocrinology
- Vol. 58 (3), 249-261
- https://doi.org/10.1046/j.1365-2265.2003.01774.x
Abstract
Postmenopausal hormonal therapy is used to manage the climacteric symptoms that impair the quality of life of a substantial number of women. The difficulty is achieving the desired effects with minimal side‐effects and no adverse health risks. Fundamental to this is understanding the physiology of oestrogen in women and the metabolism of the therapeutic compounds. Although the effects of oral oestrogen therapy have been studied extensively, there is insufficient evidence to assess adequately the independent effects of progestin use, other oestrogen compounds, differing doses and duration of treatment. We have reviewed some basic concepts of oestrogen physiology and how these relate to exogenous oestrogen administration, the risks of greatest concern, and the role of androgens and newer treatment alternatives.Keywords
This publication has 108 references indexed in Scilit:
- Serum Estradiol-Binding Profiles in Postmenopausal Women Undergoing Three Common Estrogen Replacement TherapiesMenopause, 2000
- Structure of the ligand-binding domain of oestrogen receptor beta in the presence of a partial agonist and a full antagonistThe EMBO Journal, 1999
- Prevention of Cardiovascular Events and Death with Pravastatin in Patients with Coronary Heart Disease and a Broad Range of Initial Cholesterol LevelsNew England Journal of Medicine, 1998
- Randomized Trial of Estrogen Plus Progestin for Secondary Prevention of Coronary Heart Disease in Postmenopausal WomenJAMA, 1998
- Estrogen and Progestin Compared with Simvastatin for Hypercholesterolemia in Postmenopausal WomenNew England Journal of Medicine, 1997
- Exogenous hormones, reproductive history, and colon cancer (Seattle, Washington, USA)Cancer Causes & Control, 1994
- Endothelial-dependent coronary vasomotor responsiveness in postmenopausal women with and without estrogen replacement therapyThe American Journal of Cardiology, 1994
- Skeletal effects of oral oestrogen compared with subcutaneous oestrogen and testosterone in postmenopausal women.BMJ, 1988
- Menopause and the Risk of Coronary Heart Disease in WomenNew England Journal of Medicine, 1987
- The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholineNature, 1980