Total Synthesis of Ecteinascidin 743
- 17 May 2002
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 124 (23), 6552-6554
- https://doi.org/10.1021/ja026216d
Abstract
The total synthesis of ecteinascidin 743 (1), an extremely potent antitumor agent, has been accomplished. The synthesis features Ugi's 4CC reaction, intramolecular Heck reaction, phenol−aldehyde cyclization, and acid-induced intramolecular sulfide formation.Keywords
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