Breast Implant-Associated Anaplastic Large-Cell Lymphoma Can Be a Diagnostic Challenge for Pathologists
- 19 November 2013
- journal article
- case report
- Published by S. Karger AG in Acta Cytologica
- Vol. 58 (1), 103-107
- https://doi.org/10.1159/000355861
Abstract
Background: Primary anaplastic large-cell lymphoma (ALCL) occurring in women with breast implants is very rare. It is usually described as tumor cells infiltrating the periprosthetic capsule. These are most often revealed by a periprosthetic recurrent isolated effusion (seroma cavity), occurring late after implantation of the prosthesis. ALCL is more rarely a tumor or periprosthetic capsular contracture. Case: We report a 66-year-old woman, initially diagnosed by cytological examination of breast effusion, in whom ALCL appeared two and a half months after the removal of a ruptured implant. Repeated biopsies of the periprosthetic capsule performed in parallel showed fibrous tissue, without tumor proliferation. Only meticulous histological examination of the total capsulectomy identified tumor cells as a thin and discontinuous layer along the inner surface of the capsule without capsular invasion. Conclusion: Awareness of the histological pattern of this new clinical entity is important. A total capsulectomy with a good sampling for microscopic examination should be conducted for any suspicion of breast implant-associated ALCL. Cytology-histology correlation is essential.Keywords
This publication has 13 references indexed in Scilit:
- Survival Signals and Targets for Therapy in Breast Implant–Associated ALK−Anaplastic Large Cell LymphomaClinical Cancer Research, 2012
- Brief Recommendations for Dealing with a New Case of Anaplastic Large T-Cell LymphomaPlastic and Reconstructive Surgery, 2012
- ALK-1–Negative Anaplastic Large Cell Lymphoma Associated With Breast Implants: A New Clinical EntityClinical Breast Cancer, 2011
- Anaplastic Large Cell Lymphoma and Breast ImplantsPlastic and Reconstructive Surgery, 2011
- Primary anaplastic large-cell lymphoma associated with breast implantsLeukemia & Lymphoma, 2011
- Discussion: Anaplastic Large Cell Lymphoma and Breast Implants: A Systematic ReviewPlastic and Reconstructive Surgery, 2011
- Anaplastic Large Cell Lymphoma and Breast Implants: A Systematic ReviewPlastic and Reconstructive Surgery, 2011
- Breast implant‐associated, ALK‐negative, T‐cell, anaplastic, large‐cell lymphoma: Establishment and characterization of a model cell line (TLBR‐1) for this newly emerging clinical entityCancer, 2010
- Effusion-associated anaplastic large cell lymphoma of the breast: time for it to be defined as a distinct clinico-pathological entityHaematologica, 2010
- Anaplastic Large Cell Lymphoma Associated With a Breast Implant Capsule: A Case Report and Review of the LiteratureThe American Journal of Surgical Pathology, 2008