Vaccination and Infection as Causative Factors in Japanese Patients With Rasmussen Syndrome: Molecular Mimicry and HLA Class I
Open Access
- 1 January 2006
- journal article
- Published by Hindawi Limited in Clinical and Developmental Immunology
- Vol. 13 (2-4), 381-387
- https://doi.org/10.1080/17402520600589522
Abstract
Rasmussen syndrome is an intractable epilepsy with a putative causal relation with cellular and humoral autoimmunity. Almost half of the patients have some preceding causative factors, with infections found in 38.2%, vaccinations in 5.9% and head trauma in 8.9% of Japanese patients. In a patient with seizure onset after influenza A infections, cross-reaction of the patient's lymphocytes with GluRε2 and influenza vaccine components was demonstrated by lymphocyte stimulation test. Database analyses revealed that influenza A virus hemagglutinin and GluRε2 molecules contain peptides with the patient's HLA class I binding motif (HLA ࢤ A*0201). The relative risks of HLA class I genotypes for Rasmussen syndrome are 6.1 (A*2402), 6.4 (A*0201), 6.3 (A*2601) and 11.4 (B*4601). The relative risks of HLA class I-A and B haplotypes are infinity (A*2601+B*5401), 21.1 (A*2402+B*1501), 13.3 (A*2402+B*4801) and 5.1 (A*2402+B*5201). Some alleles and haplotypes of HLA class I may be the risk factors in Japanese patients. Cross-reactivity of cytotoxic T lymphocytes may contribute to the processes leading from infection to the involvement of CNS.Keywords
Funding Information
- Ministry of Health, Labour and Welfare (15591151, 16590859, 17591133)
This publication has 6 references indexed in Scilit:
- Infections as causative factors of epilepsyFuture Neurology, 2006
- Absence of antibodies to glutamate receptor type 3 (GluR3) in Rasmussen encephalitisNeurology, 2004
- Systematic Analysis of the Combinatorial Nature of Epitopes Recognized by TCR Leads to Identification of Mimicry Epitopes for Glutamic Acid Decarboxylase 65-Specific TCRsThe Journal of Immunology, 2003
- The natural history of Rasmussen’s encephalitisBrain, 2002
- Destruction of neurons by cytotoxic T cells: A new pathogenic mechanism in rasmussen's encephalitisAnnals of Neurology, 2002
- HLA-FPublished by Elsevier BV ,2000