APOE-ε4 is not associated with cognitive impairment in relapsing—remitting multiple sclerosis
- 13 November 2009
- journal article
- other
- Published by SAGE Publications in Multiple Sclerosis Journal
- Vol. 15 (12), 1489-1494
- https://doi.org/10.1177/1352458509348512
Abstract
The objective of this article was to assess the association between apolipoprotein E (APOE)-ε4 and cognitive impairment (CI) in relapsing—remitting multiple sclerosis (RRMS). The APOE genotype was assessed in 85 RRMS cases (58 females, mean age 43 ± 8.4 years, mean disease duration 15.8 ± 9.6 years, mean Expanded Disability Status Scale (EDSS) 1.7 ± 1.0). Cognitive functioning was evaluated in the whole sample using Rao’s Brief Repeatable Battery (BRB). Performance on each test was assessed by applying the normative values for the Italian population. In a subgroup of 50 patients, a brain magnetic resonance (MR) study was performed including measurement of T2 lesion volumes (T2LV), neocortical volume (NCV) and normalized brain volume (NBV). The relationship between APOE genotype, CI and MR variables was assessed through univariate and multivariate logistic regression models. CI, most commonly involving complex attention and verbal memory tasks, was found in 28 cases (33%). We identified a total of 19 ε4carriers (22.4%), who did not differ from non-carriers regarding clinical and demographic characteristics. The presence of the ε4 genotype was associated with neither CI (p = 0.28) nor impairment on each neuropsychological test (p > 0.32; corrected for age, gender, disease duration, EDSS, depression and fatigue). The APOE genotype and CI were also not related in the subgroup of younger patients (age < 45 years; p > 0.9). Moreover, CI was related to higher T2LV (p = 0.008) and lower NCV (p = 0.006). In conclusion, in our sample CI was associated with higher subcortical damage and cortical atrophy but not with APOE-ε4 genotype. The role of APOE-ε4 as a possible biomarker in multiple sclerosis is still questionable.Keywords
This publication has 24 references indexed in Scilit:
- Cognitive changes in multiple sclerosisExpert Review of Neurotherapeutics, 2008
- APOE epsilon variation in multiple sclerosis susceptibility and disease severityNeurology, 2006
- ApoE Epsilon4 Allele and Disease Duration Affect Verbal Learning in Mild Temporal Lobe EpilepsyEpilepsia, 2005
- Cognitive Dysfunction in Early-Onset Multiple SclerosisArchives of Neurology, 2001
- Apolipoprotein E: Far More Than a Lipid Transport ProteinAnnual Review of Genomics and Human Genetics, 2000
- Potential Role of apoE in Structural Plasticity in the Nervous System: Implications for Disorders of the Central Nervous SystemTrends in Cardiovascular Medicine, 1998
- Episodic memory changes are associated with the APOE- epsilon 4 allele in nondemented older adultsNeurology, 1995
- Apolipoprotein E in animal models of CNS injury and in alzheimer's diseaseTrends in Neurosciences, 1994
- Differential Effects of Apolipoproteins E3 and E4 on Neuronal Growth in VitroScience, 1994
- Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.Proceedings of the National Academy of Sciences of the United States of America, 1993