Synthesis of colloidal aqueous suspensions of a layered gadolinium hydroxide: a potential MRI contrast agent
- 13 February 2009
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Dalton Transactions
- No. 14,p. 2490-2495
- https://doi.org/10.1039/b823172a
Abstract
A layered gadolinium hydroxychloride (LGdH), [Gd2(OH)5(H2O)x]Cl, was synthesized from an aqueous solution of GdCl3·6H2O. The X-ray diffraction (XRD) and the selected area electron diffraction (SAED) studies showed that this compound crystallizes in the orthorhombic structure (a = 12.88(4) Å, b = 7.30(2) Å, and c = 8.46(3) Å) which is isostructural with [Eu2(OH)5(H2O)x]Cl. Interestingly, this layered material was readily dispersed and led to a stable colloidal nanosheet in aqueous medium. The obtained colloidal solutions were characterized by the evaluation of their stability in acidic solution, their in vitro cytotoxicity, and their magnetic resonance imaging (MRI) relaxation properties. It is reported that the relaxometry analysis of LGdH suspensions exhibits a sufficient contrast effect for T1 weighted magnetic resonance imaging.Keywords
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