Delivery materials for siRNA therapeutics
Top Cited Papers
- 23 October 2013
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Materials
- Vol. 12 (11), 967-977
- https://doi.org/10.1038/nmat3765
Abstract
RNA interference (RNAi) has broad potential as a therapeutic to reversibly silence any gene. To achieve the clinical potential of RNAi, delivery materials are required to transport short interfering RNA (siRNA) to the site of action in the cells of target tissues. This Review provides an introduction to the biological challenges that siRNA delivery materials aim to overcome, as well as a discussion of the way that the most effective and clinically advanced classes of siRNA delivery systems, including lipid nanoparticles and siRNA conjugates, are designed to surmount these challenges. The systems that we discuss are diverse in their approaches to the delivery problem, and provide valuable insight to guide the design of future siRNA delivery materials.Keywords
This publication has 107 references indexed in Scilit:
- Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo**Angewandte Chemie-International Edition, 2012
- Comparison of Cationic and Amphipathic Cell Penetrating Peptides for siRNA Delivery and EfficacyMolecular Pharmaceutics, 2011
- Current progress of siRNA/shRNA therapeutics in clinical trialsBiotechnology Journal, 2011
- Elimination Pathways of Systemically Delivered siRNAMolecular Therapy, 2011
- Combinatorial Approach to Determine Functional Group Effects on Lipidoid-Mediated siRNA DeliveryBioconjugate Chemistry, 2010
- Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based MechanismsMolecular Therapy, 2010
- Factors Affecting the Clearance and Biodistribution of Polymeric NanoparticlesMolecular Pharmaceutics, 2008
- Sheddable Coatings for Long-Circulating NanoparticlesPharmaceutical Research, 2007
- Physicochemical and Biological Characterization of Targeted, Nucleic Acid-Containing NanoparticlesBioconjugate Chemistry, 2007
- RNA interferenceNature, 2002