Metabolic Effects of Intermittent Fasting
Top Cited Papers
- 21 August 2017
- journal article
- review article
- Published by Annual Reviews in Annual Review of Nutrition
- Vol. 37 (1), 371-393
- https://doi.org/10.1146/annurev-nutr-071816-064634
Abstract
The objective of this review is to provide an overview of intermittent fasting regimens, summarize the evidence on the health benefits of intermittent fasting, and discuss physiological mechanisms by which intermittent fasting might lead to improved health outcomes. A MEDLINE search was performed using PubMed and the terms “intermittent fasting,” “fasting,” “time-restricted feeding,” and “food timing.” Modified fasting regimens appear to promote weight loss and may improve metabolic health. Several lines of evidence also support the hypothesis that eating patterns that reduce or eliminate nighttime eating and prolong nightly fasting intervals may result in sustained improvements in human health. Intermittent fasting regimens are hypothesized to influence metabolic regulation via effects on (a) circadian biology, (b) the gut microbiome, and (c) modifiable lifestyle behaviors, such as sleep. If proven to be efficacious, these eating regimens offer promising nonpharmacological approaches to improving health at the population level, with multiple public health benefits.Keywords
This publication has 100 references indexed in Scilit:
- Time-Restricted Feeding without Reducing Caloric Intake Prevents Metabolic Diseases in Mice Fed a High-Fat DietCell Metabolism, 2012
- The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers: a randomized trial in young overweight womenInternational Journal of Obesity, 2010
- Mortality associated with short sleep duration: The evidence, the possible mechanisms, and the futureSleep Medicine Reviews, 2010
- Adverse metabolic and cardiovascular consequences of circadian misalignmentProceedings of the National Academy of Sciences of the United States of America, 2009
- Usefulness of Routine Periodic Fasting to Lower Risk of Coronary Artery Disease in Patients Undergoing Coronary AngiographyThe American Journal of Cardiology, 2008
- Short Sleep Duration and Weight Gain: A Systematic ReviewObesity, 2008
- Impact of reduced meal frequency without caloric restriction on glucose regulation in healthy, normal-weight middle-aged men and womenMetabolism, 2007
- Influence of a Diet Very High in Vegetables, Fruit, and Fiber and Low in Fat on Prognosis Following Treatment for Breast CancerJAMA, 2007
- Alternate day calorie restriction improves clinical findings and reduces markers of oxidative stress and inflammation in overweight adults with moderate asthmaFree Radical Biology & Medicine, 2007
- An obesity-associated gut microbiome with increased capacity for energy harvestNature, 2006