Blood-based diagnostics of traumatic brain injuries
- 9 January 2011
- journal article
- review article
- Published by Taylor & Francis Ltd in Expert Review of Molecular Diagnostics
- Vol. 11 (1), 65-78
- https://doi.org/10.1586/erm.10.104
Abstract
Traumatic brain injury is a major health and socioeconomic problem that affects all societies. However, traditional approaches to the classification of clinical severity are the subject of debate and are being supplemented with structural and functional neuroimaging, as the need for biomarkers that reflect elements of the pathogenetic process is widely recognized. Basic science research and developments in the field of proteomics have greatly advanced our knowledge of the mechanisms involved in damage and have led to the discovery and rapid detection of new biomarkers that were not available previously. However, translating this research for patients’ benefits remains a challenge. In this article, we summarize new developments, current knowledge and controversies, focusing on the potential role of these biomarkers as diagnostic, prognostic and monitoring tools of brain-injured patients.Keywords
This publication has 119 references indexed in Scilit:
- αII-Spectrin Breakdown Products (SBDPs): Diagnosis and Outcome in Severe Traumatic Brain Injury PatientsJournal of Neurotrauma, 2010
- Ubiquitin C‐terminal hydrolase‐L1 as a biomarker for ischemic and traumatic brain injury in ratsEuropean Journal of Neuroscience, 2010
- Ubiquitin C-terminal hydrolase is a novel biomarker in humans for severe traumatic brain injury*Critical Care Medicine, 2010
- A Panel of Neuron-Enriched Proteins as Markers for Traumatic Brain Injury in HumansJournal of Neurotrauma, 2009
- Exposure to Low-Dose Ionizing Radiation from Medical Imaging ProceduresThe New England Journal of Medicine, 2009
- αII-Spectrin Breakdown Product Cerebrospinal Fluid Exposure Metrics Suggest Differences in Cellular Injury Mechanisms after Severe Traumatic Brain InjuryJournal of Neurotrauma, 2009
- Classification of Traumatic Brain Injury for Targeted TherapiesJournal of Neurotrauma, 2008
- Gel-Based Hippocampal Proteomic Analysis 2 Weeks following Traumatic Brain Injury to Immature Rats Using Controlled Cortical ImpactDevelopmental Neuroscience, 2006
- GFAP Versus S100B in Serum after Traumatic Brain Injury: Relationship to Brain Damage and OutcomeJournal of Neurotrauma, 2004
- Traumatic Brain Damage: Serum S-100 Protein Measurements Related to Neuroradiological FindingsJournal of Neurotrauma, 2000