IL-37 is associated with osteoarthritis disease activity and suppresses proinflammatory cytokines production in synovial cells
Open Access
- 14 September 2017
- journal article
- research article
- Published by Springer Science and Business Media LLC in Scientific Reports
- Vol. 7 (1), 11601
- https://doi.org/10.1038/s41598-017-11397-5
Abstract
The objective of this study is to investigate the correlation between IL-37 level and osteoarthritis activity and to determine the anti-inflammatory effects of IL-37 in peripheral blood mononuclear cells (PBMCs) and synovial cells (SCs) from osteoarthritis (OA) patients, which including 32 patients with erosive inflammatory OA (EIOA) and 40 patients with primary generalized OA (PGOA), 40 age and sex matched healthy volunteers were recruited as healthy controls (HCs). The protein and relative mRNA levels of IL-37 were significant increased in the blood of EIOA patients compared with those of PGOA patients and HCs. Serum IL-37 levels of OA patients were positively correlated with VAS score, as well as with CRP, ESR in blood. Positive correlations were also observed among IL-37 with IL-1β, TNF-α and IL-6 in synovial cells. Furthermore, the expression of IL-1β, TNF-α and IL-6 in PBMCs and SCs from EIOA patients was suppressed by IL-37 in vitro. In conclusion, our results indicated that IL-37 increased in EIOA patients and was positively correlated with disease activity, the pro-inflammatory cytokines such as IL-1β, TNF-α and IL-6 in PBMCs and synovial cells from EIOA patients were restrained by recombinant IL-37. Thus, IL-37 may serve as a novel therapeutic target for the treatment of OA inflammation.Keywords
This publication has 41 references indexed in Scilit:
- Interleukin 37 expression protects mice from colitisProceedings of the National Academy of Sciences of the United States of America, 2011
- IL-37 is a fundamental inhibitor of innate immunityNature Immunology, 2010
- Synovitis detected on magnetic resonance imaging and its relation to pain and cartilage loss in knee osteoarthritisAnnals Of The Rheumatic Diseases, 2007
- Evidencia de mecanismos inflamatorios en la osteoartritisReumatología Clínica, 2007
- Elevated serum levels of soluble interleukin-4 receptor in osteoarthritisOsteoarthritis and Cartilage, 2006
- Synovitis: a potential predictive factor of structural progression of medial tibiofemoral knee osteoarthritis – results of a 1 year longitudinal arthroscopic study in 422 patientsOsteoarthritis and Cartilage, 2005
- Aging Theories of Primary Osteoarthritis: From Epidemiology to Molecular BiologyRejuvenation Research, 2004
- Tumor necrosis factor alpha can contribute to focal loss of cartilage in osteoarthritisOsteoarthritis and Cartilage, 2000
- The Biology of OsteoarthritisNew England Journal of Medicine, 1989
- Criteria for the Classification of Osteoarthritis of the Knee and HipScandinavian Journal of Rheumatology, 1987