Cribriform‐morular variant of papillary thyroid carcinoma—Cytological and immunocytochemical findings of 18 cases
- 19 November 2010
- journal article
- research article
- Published by Wiley in Diagnostic Cytopathology
- Vol. 38 (12), 890-896
- https://doi.org/10.1002/dc.21309
Abstract
The purpose of this article was to describe cytologic findings of cribriform-morular variant of papillary thyroid carcinoma (CMV-PTC) in detail, to review previously reported cases, and to emphasize the diagnostic significance of this subtype. We examined 19 ultrasound-guided fine needle aspiration (FNA) specimens from 18 CMV-PTC patients. Cytologic features of CMV-PTC were as follows, (1) hypercellularity, (2) papillary arrangement composed of tall columnar cells, (3) cribriform pattern, (4) morules, (5) spindle cells, (6) obscure ground-glass nuclei, (7) peculiar nuclear clearing (PNC), (8) foamy or hemosiderin-laden histiocytes, (9) hyaline materials, (10) absence of colloid in the background. The nuclear and cytoplasmic immunoreactivity of beta-catenin and biotin-positive PNC can indicate CMV-PTC. We believe that cytologic diagnosis of CMV-PTC is possible and it may lead to the early detection of polyposis coli. Diagn. Cytopathol. 2010;38:890–896.Keywords
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