Limitations of a Molecular Clock Applied to Considerations of the Origin of HIV-1
- 19 June 1998
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 280 (5371), 1868-1871
- https://doi.org/10.1126/science.280.5371.1868
Abstract
A recent report has provided information that helps to determine the age of a common viral ancestor of the AIDS epidemic. Korber et al . examine the strengths as well as limitations of molecular clock analysis and the implications of the findings for planning vaccines and forecasting the future of the epidemic.Keywords
This publication has 17 references indexed in Scilit:
- Diversity of the Human Immunodeficiency Virus Type 1 Envelope Glycoprotein in San Francisco Men's Health Study ParticipantsAIDS Research and Human Retroviruses, 1998
- Molecular SystematicsIchthyology & Herpetology, 1996
- Sequence Note: Rapid Sequon Evolution in Human Immunodeficiency Virus Type 1 Relative to Human Immunodeficiency Virus Type 2AIDS Research and Human Retroviruses, 1996
- On the nature of virus quasispeciesTrends in Microbiology, 1996
- HIV-1 Dynamics in Vivo: Virion Clearance Rate, Infected Cell Life-Span, and Viral Generation TimeScience, 1996
- Antigenic oscillations and shifting immunodominance in HIV-1 infectionsNature, 1995
- Time from HIV seroconversion to oral candidiasis or hairy leukoplakia among homosexual and bisexual men enrolled in three prospective cohortsAIDS, 1994
- Phylogenetic analysis of gag genes from 70 international HIV-1 isolates provides evidence for multiple genotypesAIDS, 1993
- Genetic organization of a chimpanzee lentivirus related to HIV-1Nature, 1990
- Understanding the origins of AIDS virusesNature, 1988