The Risk of Parkinson Disease Associated with Urate in a Community-Based Cohort of Older Adults
Open Access
- 16 June 2011
- journal article
- research article
- Published by S. Karger AG in Neuroepidemiology
- Vol. 36 (4), 223-229
- https://doi.org/10.1159/000327748
Abstract
Background/Aims: Studies suggest an inverse association between urate concentration and the risk of Parkinson disease (PD). We investigated this in the Cardiovascular Health Study in an elderly community-based cohort of adults. Methods: The association of baseline urate (µmol/l) and incident PD over 14 years was assessed with locally weighted scatterplot smoothing (LOESS) regression from which categories of low (500 µmol/l) urate ranges were derived. Multivariate logistic regression models assessed the risk of PD for each urate range. Linear and quadratic terms were tested when modeling the association between urate and the risk of PD. Results: Women had significantly lower urate concentrations than did men [316.8 µmol/l (SD 88.0) vs. 367.4 µmol/l (SD 87.7), p < 0.0001] and in women no associations between urate and PD risk were observed. In men, LOESS curves suggested a U-shaped or threshold effect between urate and PD risk. With the middle range as reference, the risk of developing PD was significantly increased for urate 500 µmol/l (OR 1.55, 95% CI 0.72–3.32) in men. A negative linear term was significant for urate Conclusions: Results suggest a more complex relationship than previously reported between urate levels and the risk of PD in men. Low urate concentrations were associated with a higher PD risk and high urate concentrations were not associated with a further decrease in PD risk.Keywords
This publication has 25 references indexed in Scilit:
- Plasma Urate and Parkinson's Disease in WomenAmerican Journal of Epidemiology, 2010
- Association between hyperuricemia and incident heart failure among older adults: A propensity-matched studyInternational Journal of Cardiology, 2010
- Case–control study of risk of Parkinson's disease in relation to hypertension, hypercholesterolemia, and diabetes in JapanJournal of the Neurological Sciences, 2010
- Multi-organ distribution of phosphorylated α-synuclein histopathology in subjects with Lewy body disordersActa Neuropathologica, 2010
- Post Hoc Parkinson’s Disease: Identifying an Uncommon Disease in the Cardiovascular Health StudyNeuroepidemiology, 2010
- Plasma Urate and Parkinson's Disease in the Atherosclerosis Risk in Communities (ARIC) StudyAmerican Journal of Epidemiology, 2009
- Prevalence, Prognosis, and Implications of Isolated Minor Nonspecific ST-Segment and T-Wave Abnormalities in Older AdultsCirculation, 2008
- The paradoxical relationship between serum uric acid and cardiovascular diseaseClinica Chimica Acta; International Journal of Clinical Chemistry, 2008
- Plasma Urate and Risk of Parkinson's DiseaseAmerican Journal of Epidemiology, 2007
- Cardiovascular Mortality Risk in Chronic Kidney DiseaseJAMA, 2005