Usefulness of Faecal Calprotectin Measurement in Children with Various Types of Inflammatory Bowel Disease
Open Access
- 14 May 2012
- journal article
- research article
- Published by Hindawi Limited in Mediators of Inflammation
- Vol. 2012, 1-5
- https://doi.org/10.1155/2012/608249
Abstract
Introduction. The aim of the study was to assess the usefulness of the FC measurement in children with various types of IBD and relation to the disease activity.Patients and Methods. 91 patients (49 boys: 53.85% and 42 girls: 46.15%, mean age: 13.38 years, range 6–18 years) were included in the analysis. Patients were divided into the groups: B1—24 children with CD, B2—16 patients with UC, and a group comprising 31 children with other types of colitis; the control group (K) comprised 20 healthy children. FC was assayed by ELISA method, using Phical test (Calpro).Results. The mean faecal calprotectin concentrations were higher in children with CD and UC as compared to healthy controls, patients with eosinophilic, lymphocytic, and nonspecific colitis. A positive correlation was observed between FC concentrations and the disease activity (the PCDAI scale, the Truelove-Witts Scale, and the endoscopic Rachmilewitz Index).Conclusion. It seems that the FC concentrations can be a useful, safe, and noninvasive test in children suspected for IBD, since FC concentration is higher in children with CD and UC than in patients with other inflammatory diseases.Keywords
This publication has 16 references indexed in Scilit:
- Fecal Calprotectin and Lactoferrin as Noninvasive Markers of Pediatric Inflammatory Bowel DiseaseJournal of Pediatric Gastroenterology and Nutrition, 2009
- Role of fecal calprotectin as a biomarker of intestinal inflammation in inflammatory bowel diseaseInflammatory Bowel Diseases, 2006
- S100 proteins in the pathogenesis and diagnosis of inflammatory bowel diseaseExpert Review of Clinical Immunology, 2006
- Combined Use of Noninvasive Tests is Useful in the Initial Diagnostic Approach to a Child with Suspected Inflammatory Bowel DiseaseJournal of Pediatric Gastroenterology and Nutrition, 2006
- Colorectal Inflammation is Well Predicted by Fecal Calprotectin in Children with Gastrointestinal SymptomsJournal of Pediatric Gastroenterology and Nutrition, 2005
- Calprotectin is a stronger predictive marker of relapse in ulcerative colitis than in Crohn's diseaseGut, 2005
- Normalization of faecal calprotectin: a predictor of mucosal healing in patients with inflammatory bowel diseaseScandinavian Journal of Gastroenterology, 2004
- Diagnostic Accuracy of Fecal Calprotectin Assay in Distinguishing Organic Causes of Chronic Diarrhea from Irritable Bowel Syndrome: A Prospective Study in Adults and ChildrenClinical Chemistry, 2003
- Fecal Calprotectin: Validation as a Noninvasive Measure of Bowel Inflammation in Childhood Inflammatory Bowel DiseaseJournal of Pediatric Gastroenterology and Nutrition, 2001
- Non-invasive investigation of inflammatory bowel diseaseWorld Journal of Gastroenterology, 2001