Molecular basis for changes in behavioral state in ant social behaviors
- 14 April 2009
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences of the United States of America
- Vol. 106 (15), 6351-6356
- https://doi.org/10.1073/pnas.0809463106
Abstract
A hallmark of behavior is that animals respond to environmental change by switching from one behavioral state to another. However, information on the molecular underpinnings of these behavioral shifts and how they are mediated by the environment is lacking. The ant Pheidole pallidula with its morphologically and behaviorally distinct major and minor workers is an ideal system to investigate behavioral shifts. The physically larger majors are predisposed to defend the ant nest, whereas the smaller minors are the foragers. Despite this predisposition, majors are able to shift to foraging according to the needs of the colony. We show that the ant foraging (ppfor) gene, which encodes a cGMP-dependent protein kinase (PKG), mediates this shift. Majors have higher brain PKG activities than minors, and the spatial distribution of the PPFOR protein differs in these workers. Specifically, majors express the PPFOR protein in 5 cells in the anterior face of the ant brain, whereas minors do not. Environmental manipulations show that PKG is lower in the presence of a foraging stimulus and higher when defense is required. Finally, pharmacological activation of PKG increases defense and reduces foraging behavior. Thus, PKG signaling plays a critical role in P. pallidula behavioral shifts.This publication has 22 references indexed in Scilit:
- The foraging gene of Drosophila melanogaster: Spatial‐expression analysis and sucrose responsivenessJournal of Comparative Neurology, 2007
- Natural polymorphism affecting learning and memory in DrosophilaProceedings of the National Academy of Sciences of the United States of America, 2007
- Natural variation in Drosophila larval reward learning and memory due to a cGMP-dependent protein kinaseLearning & Memory, 2007
- Bruchpilot, a Protein with Homology to ELKS/CAST, Is Required for Structural Integrity and Function of Synaptic Active Zones in DrosophilaNeuron, 2006
- Function of cGMP-Dependent Protein Kinases as Revealed by Gene DeletionPhysiological Reviews, 2006
- Candidate genes for behavioural ecologyTrends in Ecology & Evolution, 2005
- Phenotypic deconstruction reveals involvement of manganese transportermalvolioin honey bee division of laborJournal of Experimental Biology, 2004
- Regulation of Body Size and Behavioral State of C. elegans by Sensory Perception and the EGL-4 cGMP-Dependent Protein KinaseNeuron, 2002
- Influence of Gene Action Across Different Time Scales on BehaviorScience, 2002
- Increased soldier production in ant colonies exposed to intraspecific competitionNature, 1996