Regulatory T cells: immune suppression and beyond
- 12 April 2010
- journal article
- review article
- Published by Springer Science and Business Media LLC in Cellular & Molecular Immunology
- Vol. 7 (3), 204-210
- https://doi.org/10.1038/cmi.2010.20
Abstract
Foxp3-expressing regulatory T cells (Tregs) were originally identified as critical in maintaining self-tolerance and immune homeostasis. The immunosuppressive functions of Tregs are widely acknowledged and have been extensively studied. Recent studies have revealed many diverse roles of Tregs in shaping the immune system and the inflammatory response. This review will discuss our efforts as well as the efforts of others towards understanding the multifaceted function of Tregs in immune regulation.Keywords
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