Effects of dexmedetomidine pretreatment on heme oxygenase-1 expression and oxidative stress during one-lung ventilation.
- 1 March 2015
- journal article
- research article
- Vol. 8 (3), 3144-9
Abstract
This study aimed to explore effects of dexmedetomidine pretreatment on heme oxygenase-1 (HO-1) expression and oxidative stress during one-lung ventilation (OLV) in lung cancer patients. Fifty patients with lung carcinoma (ASA I-II, 40-65 years old, body mass index [BMI]0.05). Levels of tumor necrosis factor (TNF-α) and malondialdehyde (MDA) in Dexmedetomidine group were lower than that of Control at OLV 60 and 90 (P<0.05). Superoxide dismutase (SOD) activity and the expression level of HO-1 were higher in Dexmedetomidine group than in Control (P<0.05). Dexmedetomidine pretreatment could upregulated expression of HO-1 in lung tissue and reduce oxidative stress and inflammation during OLV. Thus dexmedetomidine played a role in protecting lung injury by promoting HO-1 expression.Keywords
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