Deciphering the effect of reproductive tract microbiota on human reproduction
Open Access
- 1 November 2018
- journal article
- review article
- Published by Wiley in Reproductive Medicine and Biology
- Vol. 18 (1), 40-50
- https://doi.org/10.1002/rmb2.12249
Abstract
Background The female reproductive tract contains an active microbiome comprising mainly bacteria from the Lactobacillus genus, which is associated with a healthy microbiome state. However, spatio‐temporal fluctuations of this microbiome that occur in response to internal and external factors may impact the physiology of the reproductive tract organs and even lead to pathological states. Methods Current literature covering the reproductive tract microbiome is summarized and contextualized in this review. Main findings This review presents the current knowledge about the bacterial composition of the lower and upper reproductive tract as well as the impact of the microbiota on women's health and reproduction. We place special focus on the impact of the endometrial microbiome in infertility and assisted reproductive technologies. Conclusion The assessment of the reproductive tract microbiome adds a new microbiological perspective to human reproduction, pregnancy, and onset of new life, highlighting the importance of considering the evaluation of microbial communities to improve personalized care in reproductive medicine and women's health.Keywords
This publication has 104 references indexed in Scilit:
- Diversity of the Vaginal Microbiome Correlates With Preterm BirthReproductive Sciences, 2014
- A Metagenomic Approach to Characterization of the Vaginal Microbiome Signature in PregnancyPLOS ONE, 2012
- Structure, function and diversity of the healthy human microbiomeNature, 2012
- A framework for human microbiome researchNature, 2012
- Efficacy of Oral Metronidazole with Vaginal Clindamycin or Vaginal Probiotic for Bacterial Vaginosis: Randomised Placebo-Controlled Double-Blind TrialPLOS ONE, 2012
- The dynamics of the vaginal microbiome during infertility therapy with in vitro fertilization-embryo transferJournal of Assisted Reproduction and Genetics, 2012
- Prevalence and Diversity of Microbes in the Amniotic Fluid, the Fetal Inflammatory Response, and Pregnancy Outcome in Women with Preterm Pre‐Labor Rupture of MembranesAmerican Journal of Reproductive Immunology, 2010
- Vaginal microbiome of reproductive-age womenProceedings of the National Academy of Sciences of the United States of America, 2010
- Temporal Variability of Human Vaginal Bacteria and Relationship with Bacterial VaginosisPLOS ONE, 2010
- Examination of bacterial contamination at the time of embryo transfer, and its impact on the IVF/pregnancy outcomeJournal of Assisted Reproduction and Genetics, 2007