Prevention of Oxidative Stress-Induced Retinal Pigment Epithelial Cell Death by the PPARAgonist, 15-Deoxy-Delta 12, 14-Prostaglandin
Open Access
- 1 January 2008
- journal article
- review article
- Published by Hindawi Limited in PPAR Research
- Vol. 2008, 1-7
- https://doi.org/10.1155/2008/720163
Abstract
Cellular oxidative stress plays an important role in retinal pigment epithelial (RPE) cell death during aging and the development of age-related macular degeneration. Early reports indicate that during phagocytosis of rod outer segments, there is an increase of RPE oxidative stress and an upregulation of PPARmRNA in these cells. These studies suggest that activation of PPARmay modulate cellular oxidative stress. This paper presents a brief review of recent studies that investigate RPE oxidative stress under various experimental conditions. This is followed by a detailed review on those reports that examine the protective effect of the natural PPARligand, 15d-PG, against RPE oxidative stress. This agent can upregulate glutathione and prevent oxidant-induced intracellular reactive oxygen species accumulation, mitochondrial depolarization, and apoptosis. The cytoprotective effect of this agent, however, is not shared by other PPARagonists. Nonetheless, this property of 15d-PGmay be useful in future development of pharmacological tools against retinal diseases caused by oxidative stress.
Keywords
Funding Information
- Prevent Blindness America
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