A randomized, placebo-controlled study of oxcarbazepine in painful diabetic neuropathy
- 1 August 2006
- journal article
- research article
- Published by Hindawi Limited in Acta Neurologica Scandinavica
- Vol. 114 (3), 177-180
- https://doi.org/10.1111/j.1600-0404.2005.00559.x
Abstract
Objectives: To evaluate the efficacy and safety of oxcarbazepine (1200 mg/day) in patients with painful diabetic neuropathy in a multicentre, double‐blind, placebo‐controlled, 16‐week study. Methods: A total of 141 patients were randomized to oxcarbazepine (1200 mg/day) (n = 71) or placebo (n = 70). The primary efficacy variable was the change in mean visual analogue scale (VAS) score from baseline to the last week the patient participated in the study. Results: The reduction in mean VAS score from baseline to the last study week was similar between the oxcarbazepine and placebo groups. The majority of adverse events (most of which first occurred during titration) were mild to moderate in severity and resolved over the course of the study. Conclusions: In this study, no statistically significant difference in therapeutic effect was observed between oxcarbazepine (1200 mg/day) and placebo. However, further studies are necessary to assess the effective dose range of oxcarbazepine in the treatment of painful diabetic neuropathy.Keywords
This publication has 7 references indexed in Scilit:
- Oxcarbazepine in painful diabetic neuropathy: results of a dose-ranging studyActa Neurologica Scandinavica, 2006
- Oxcarbazepine in painful diabetic neuropathy: a randomized, placebo‐controlled studyEuropean journal of pain, 2005
- Topiramate in painful diabetic polyneuropathy: findings from three double-blind placebo-controlled trialsActa Neurologica Scandinavica, 2004
- Current pharmacologic approaches to treating neuropathic painCurrent Pain and Headache Reports, 2004
- Gabapentin dosing for neuropathic pain: Evidence from randomized, placebo-controlled clinical trialsClinical Therapeutics, 2003
- Clinical importance of changes in chronic pain intensity measured on an 11-point numerical pain rating scalePain, 2001
- A double-blind study comparing oxcarbazepine and carbamazepine in patients with newly diagnosed, previously untreated epilepsyEpilepsy Research, 1989