Abdominal segmentation, pole cell formation, and embryonic polarity require the localized activity of oskar, a maternal gene in drosophila
- 1 October 1986
- journal article
- research article
- Published by Elsevier BV in Cell
- Vol. 47 (1), 141-152
- https://doi.org/10.1016/0092-8674(86)90375-2
Abstract
Embryos derived from oskar females lack pole cells and the specialized pole plasm including polar granules. In addition, the abdominal region remains unsegmented and eventually dies. Transplantation of cytoplasm from normal embryos into mutant embryos reveals that osk-dependent activity is strictly localized at the posterior pole and has three distinct functions. In mutant embryos the activity will normalize pole cell formation when transplanted into the posterior pole and abdominal segmentation after transplantation to a more anterior, the prospective abdominal, region. Furthermore, osk activity can provoke the formation of a second " posterior center" at the anterior. The participation of the osk product in the establishment of a source of morphogenetic activity in the posterior pole plasm is discussed.This publication has 25 references indexed in Scilit:
- tudor, a gene required for assembly of the germ plasm in Drosophila melanogasterCell, 1985
- Information for the dorsal–ventral pattern of the Drosophila embryo is stored as maternal mRNANature, 1984
- Developmental analysis of the grandchildless (gs(1)N26) mutation in Drosophila melanogaster: Abnormal cleavage patterns and defects in pole cell formationDevelopmental Biology, 1984
- Different requirements for homeotic genes in the soma and germ line of DrosophilaCell, 1983
- Mutations affecting segment number and polarity in DrosophilaNature, 1980
- The ontogeny of germ plasm during oogenesis in DrosophilaDevelopmental Biology, 1976
- Developmental defects of female-sterile mutants of Drosophila melanogasterDevelopmental Biology, 1975
- Polar granules of Drosophila. IV. Cytochemical studies showing loss of RNA from polar granules during early stages of embryogenesisJournal of Experimental Zoology, 1971
- Bicaudal, a genetic factor which affects the polarity of the embryo in Drosophila melanogasterJournal of Experimental Zoology, 1966
- Fine structure of pole cells and polar granules in Drosophila melanogasterJournal of Experimental Zoology, 1962