microRNA expression profiling identifies a four microRNA signature as a novel diagnostic and prognostic biomarker in triple negative breast cancers
Open Access
- 21 January 2014
- journal article
- research article
- Published by Impact Journals, LLC in Oncotarget
- Vol. 5 (5), 1174-1184
- https://doi.org/10.18632/oncotarget.1682
Abstract
Triple Negative Breast Cancers (TNBC) is a heterogeneous disease at the molecular and clinical level with poor outcome. Molecular subclassification of TNBCs is essential for optimal use of current therapies and for development of new drugs. microRNAs (miRNA) are widely recognized as key players in cancer progression and drug resistance; investigation of their involvement in a TNBC cohort may reveal biomarkers for diagnosis and prognosis of TNBC. Here we stratified a large TNBC cohort into Core Basal (CB, EGFR and/or CK5, 6 positive) and five negative (5NP) if all markers are negative. We determined the complete miRNA expression profile and found a subset of miRNAs specifically deregulated in the two subclasses.Keywords
This publication has 46 references indexed in Scilit:
- Comprehensive molecular portraits of human breast tumoursNature, 2012
- Stem cell-related markers in primary breast cancers and associated metastatic lesionsLaboratory Investigation, 2012
- Breast cancer stem cellsThe International Journal of Biochemistry & Cell Biology, 2012
- Deconstructing the molecular portraits of breast cancerMolecular Oncology, 2010
- Modulation of mismatch repair and genomic stability by miR-155Proceedings of the National Academy of Sciences, 2010
- MicroRNAs: Target Recognition and Regulatory FunctionsCell, 2009
- The impact of microRNAs on protein outputNature, 2008
- Race, Breast Cancer Subtypes, and Survival in the Carolina Breast Cancer StudyJAMA, 2006
- Pre-B cell proliferation and lymphoblastic leukemia/high-grade lymphoma in Eμ-miR155 transgenic miceProceedings of the National Academy of Sciences, 2006
- Expression of luminal and basal cytokeratins in human breast carcinomaThe Journal of Pathology, 2004