Angiocentric nasal T/natural killer cell lymphoma: a single centre study of prognostic factors in 108 patients
- 1 August 2000
- journal article
- research article
- Published by Wiley in Clinical and Laboratory Haematology
- Vol. 22 (4), 215-220
- https://doi.org/10.1046/j.1365-2257.2000.00307.x
Abstract
Angiocentric T cell/natural killer (NK) nasal lymphoma remains a rare clinical presentation in North America and Europe but is more common in Asia and Latin America. We have reviewed 108 cases of angiocentric T/NK cell lymphoma of the nasal cavity with a view to establishing prognostic factors. Most patients were high or high intermediate clinical risk and had additional poor prognostic factors such as bulky disease, high levels of beta 2 microglobulin, advanced stage and multiple extranodal involvement. At 8 years, overall survival was 82%, 90% and 84% for low–intermediate, high–intermediate and high clinical, respectively. Disease free survival was very similar: 79%, 83% and 80%, respectively. Multivariate analysis did not identify any factor influencing overall survival and disease‐free survival. There was no evidence that the international prognostic index (IPI) was applicable in these patients and it appears that angiocentric T/NK cell lymphoma is an independent prognostic factor itself.Keywords
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