C–H Functionalization at Sterically Congested Positions by the Platinum-Catalyzed Borylation of Arenes
Open Access
- 17 September 2015
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 137 (38), 12211-12214
- https://doi.org/10.1021/jacs.5b07677
Abstract
Despite significant progress in the area of C-H bond functionalization of arenes, no general method has been reported for the functionalization of C-H bonds at the sterically encumbered positions of simple arenes, such as mesitylene. Herein, we report the development of the first platinum-based catalyst for C-H borylation of arenes and heteroarenes. Notably, this method exhibited high tolerance toward steric hindrance and provided rapid access to a series of 2,6-disubstituted phenylboronic esters, valuable building blocks for further elaborations.Funding Information
- Ministry of Education, Culture, Sports, Science, and Technology
- Japan Society for the Promotion of Science
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