Effect of Steel and Teflon Infusion Catheters on Subcutaneous Adipose Tissue Blood Flow and Infusion Counter Pressure in Humans
- 1 May 2009
- journal article
- Published by Mary Ann Liebert Inc in Diabetes Technology & Therapeutics
- Vol. 11 (5), 301-306
- https://doi.org/10.1089/dia.2008.0061
Abstract
Subcutaneous tissue is an important target for drug deposition or infusion. A local trauma may induce alterations in local microcirculation and diffusion barriers with consequences for drug bioavailability. We examined the influence of infusion catheters' wear time on local microcirculation and infusion counter pressure.One steel catheter and one Teflon (Dupont, Wilmington, DE) catheter were inserted in subcutaneous, abdominal adipose tissue (SCAAT) in 10 healthy, lean men. The catheters were infused with isotonic saline at a rate of 10 microL/h for 48 h. Another steel catheter and a Teflon catheter were inserted contralateral to the previous catheters after 48 h. The infusion counter pressure was measured during a basal infusion rate followed by a bolus infusion. The measurements during a basal rate infusion were repeated after the bolus infusion. Adipose tissue blood flow (ATBF) was measured in SCAAT continuously.A significant increase in ATBF was observed with wear time for Teflon but not for steel catheters. Mean infusion pressure during the bolus phase increased significantly from 0 to 48 h for Teflon but not for steel catheters. ATBF and infusion counter pressure was similar between Teflon and steel catheters after acute catheter implantation and after wear time of 48 h. The maximum value of pressure during the bolus phase increased with wear time of a catheter.ATBF and bolus mean infusion pressure increased significantly with a wear time of 48 h in Teflon but not in steel catheters. The maximal pressure required to deliver a bolus infusion increased with wear time of a catheter. A higher maximal pressure was required to deliver a bolus infusion through a Teflon than through a steel catheter. We propose that the difference in infusion counter pressure and ATBF between Teflon and steel catheters with wear time may be explained by better biocompatibility of steel than Teflon.Keywords
This publication has 13 references indexed in Scilit:
- Subcutaneous infusion: non-metal cannulae vs metal butterfly needlesBritish Journal of Community Nursing, 2002
- Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)The Lancet, 1998
- Unchanged Insulin Absorption After 4 Days' Use of Subcutaneous Indwelling Catheters for Insulin InjectionsDiabetes Care, 1997
- A prospective comparison study between a butterfly needle and a Teflon cannula for subcutaneous narcotic administrationJournal of Pain and Symptom Management, 1994
- Insulin Administration via a Subcutaneous Catheter: Effects on absorptionDiabetes Care, 1993
- No Pharmacokinetic Effect of Retaining the Infusion Site up to Four Days During Continuous Subcutaneous Insulin Infusion TherapyDiabetic Medicine, 1993
- Insulin absorption is faster when keeping the infusion site in use for three days during continuous subcutaneous insulin infusionDiabetes Research and Clinical Practice, 1991
- Tissue/blood partition coefficients for xenon in various adipose tissue depots in manScandinavian Journal of Clinical and Laboratory Investigation, 1987
- Diffusion and polymerization determines the insulin absorption from subcutaneous tissue in diabetic patientsScandinavian Journal of Clinical and Laboratory Investigation, 1985
- Adipose tissue blood flow and insulin disappearance from subcutaneous tissueCancer Cell, 1979