The Facile Synthesis of N(1), N(4)-Dimethyl-5-substituted Cytosines
- 1 November 1992
- journal article
- research article
- Published by Informa UK Limited in Synthetic Communications
- Vol. 22 (20), 2927-2934
- https://doi.org/10.1080/00397919208021116
Abstract
A facile, high yield synthesis of N(1), N(4)-dimethyl-5-alkyl (methyl, ethyl, n-propyl, n-butyl) cytosines has been described. This method seems to be an alternative and universal route to N(1), N(4)-methylated cytosines with any 5-substituent.Keywords
This publication has 16 references indexed in Scilit:
- The Efficient Method of Synthesis of 4-N-ArylcytosinesSynthetic Communications, 1990
- Nucleosides. 123. Synthesis of antiviral nucleosides: 5-substituted 1-(2-deoxy-2-halogeno-.beta.-D-arabinofuranosyl)cytosines and -uracils. Some structure-activity relationshipsJournal of Medicinal Chemistry, 1983
- Nucleosides. 110. Synthesis and antiherpes virus activity of some 2'-fluoro-2'-deoxyarabinofuranosylpyrimidine nucleosidesJournal of Medicinal Chemistry, 1979
- 5-Alkylpyrimidine nucleosides. Preparation and properties of 5-ethyl-2'-deoxycytidine and related nucleosidesJournal of Medicinal Chemistry, 1974
- Preparation of a number of 5-butylpyrimidine nucleosidesJournal of Medicinal Chemistry, 1972
- Thiation of Nucleosides. II. Synthesis of 5-Methyl-2'-deoxycytidine and Related Pyrimidine Nucleosides1Journal of the American Chemical Society, 1959
- Spectrophotometric studies on nucleic acid derivatives and related compounds as a function of pH: II. Natural and synthetic pyrimidine nucleosidesBiochimica et Biophysica Acta, 1952
- Action of Alkali on 2,4-Diethoxypyrimidine and the Application of the Reaction to a New Synthesis of Cytosine: The Refractive Indices of Some PyrimidinesJournal of the American Chemical Society, 1935
- RESEARCHES ON PYRIMIDINES. CXV. ALKYLATION ON NITROGEN OF THE PYRIMIDINE CYCLE BY APPLICATION OF A NEW TECHNIQUE INVOLVING MOLECULAR REARRANGEMENTSJournal of the American Chemical Society, 1930
- RESEARCHES ON PYRIMIDINES. CXIII. AN IMPROVED METHOD FOR THE SYNTHESIS OF CYTOSINE1Journal of the American Chemical Society, 1930