Longitudinal weight gain in women identified With polycystic ovary syndrome: Results of an observational study in young women
Top Cited Papers
- 2 July 2013
- Vol. 21 (8), 1526-1532
- https://doi.org/10.1002/oby.20213
Abstract
Objective Polycystic ovary syndrome (PCOS) affects 6‐18% of women. The natural history of weight gain in women with PCOS has not been well described. Here we aimed to examine longitudinal weight gain in women with and without PCOS and to assess the association between obesity and PCOS prevalence. Design and Methods The observational study was set in the general community. Participants were women randomly selected from the national health insurance scheme (Medicare) database. Mailed survey data were collected by the Australian Longitudinal Study on Women's Health. Data from respondents to survey 4, aged 28‐33 years (2006, n = 9,145) were analyzed. The main outcome measures were PCOS prevalence and body mass index (BMI). Results Self‐reported PCOS prevalence was 5.8% (95% CI: 5.3%‐6.4%). Women reporting PCOS had higher weight, mean BMI [2.5 kg/m2 (95% CI: 1.9‐3.1)], and greater 10‐year weight gain [2.6 kg (95% CI: 1.2‐4.0)]. BMI was the strongest correlate of PCOS status with every BMI increment increasing the risk of reporting PCOS by 9.2% (95% CI: 6%‐12%). Conclusions This community based observational study with longitudinal reporting of weight shows that weight, BMI, and 10‐year weight gain were higher in PCOS. We report the novel finding that obesity and greater weight gain are significantly associated with PCOS status. Considering the prevalence, major health and economic burden of PCOS, the increasing weight gain in young women, and established benefits of weight loss, these results have major public health implications.Keywords
This publication has 27 references indexed in Scilit:
- Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespanBMC Medicine, 2010
- The prevalence of polycystic ovary syndrome in a community sample assessed under contrasting diagnostic criteriaHuman Reproduction, 2009
- Withdrawn: Postmenopausal Women with a History of Irregular Menses and Elevated Androgen Measurements at High Risk for Worsening Cardiovascular Event-Free Survival: Results from the National Institutes of Health—National Heart, Lung, and Blood Institute Sponsored Women’s Ischemia Syndrome EvaluationJournal of Clinical Endocrinology & Metabolism, 2008
- The management of insulin resistance in polycystic ovary syndromeTrends in Endocrinology & Metabolism, 2007
- Criteria for Defining Polycystic Ovary Syndrome as a Predominantly Hyperandrogenic Syndrome: An Androgen Excess Society GuidelineJournal of Clinical Endocrinology & Metabolism, 2006
- Vascular Dysfunction and Metabolic Parameters in Polycystic Ovary SyndromeJournal of Clinical Endocrinology & Metabolism, 2005
- The Prevalence and Features of the Polycystic Ovary Syndrome in an Unselected PopulationJournal of Clinical Endocrinology & Metabolism, 2004
- Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndromeFertility and Sterility, 2004
- A Prospective Study of the Prevalence of the Polycystic Ovary Syndrome in Unselected Caucasian Women from SpainJournal of Clinical Endocrinology & Metabolism, 2000
- A Survey of the Polycystic Ovary Syndrome in the Greek Island of Lesbos: Hormonal and Metabolic ProfileJournal of Clinical Endocrinology & Metabolism, 1999