Immune regulation by mesenchymal stem cells: two sides to the coin
- 13 December 2006
- journal article
- review article
- Published by Wiley in Tissue Antigens
- Vol. 69 (1), 1-9
- https://doi.org/10.1111/j.1399-0039.2006.00739.x
Abstract
Mesenchymal stem cells (MSCs) constitute a rare population of adult stem cells that can be isolated from a simple bone marrow aspirate in the absence of prior mobilization. For this reason, MSCs are particularly attractive for cell-based medicine. Ex-vivo-expanded MSCs isolated from different species, including human MSCs, have been shown to suppress the activity of a broad range of immune cells, including T cells, antigen-presenting cells, natural killer (NK) cells and B cells. New studies have further shown that MSCs interact with NK cells, express NK cell receptor ligands, express Toll-like receptors (TLRs), respond to TLR ligands and act as antigen-presenting cells upon interferon-gamma stimulation. Taken together, these studies suggest that MSCs may constitute a previously unrecognized player of the immune system with dichotomy of function reminiscent of other antigen-presenting cells. An important question that remains unanswered is whether resident MSCs actually play a role in endogenous immune responses? I here review the mechanisms of MSC-mediated immune regulation and discuss the major roles of resident MSCs in health and disease.Keywords
This publication has 56 references indexed in Scilit:
- Donor-derived mesenchymal stem cells are immunogenic in an allogeneic host and stimulate donor graft rejection in a nonmyeloablative settingBlood, 2006
- Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcomaThe Journal of Experimental Medicine, 2006
- Allogeneic marrow stromal cells are immune rejected by MHC class I– and class II–mismatched recipient miceBlood, 2005
- Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergyPublished by American Society of Hematology ,2005
- Bone marrow mesenchymal progenitor cells inhibit lymphocyte proliferation by activation of the programmed death 1 pathwayEuropean Journal of Immunology, 2005
- Bone marrow mesenchymal stem cells induce division arrest anergy of activated T cellsBlood, 2005
- Dkk-1-derived Synthetic Peptides and Lithium Chloride for the Control and Recovery of Adult Stem Cells from Bone MarrowJournal of Biological Chemistry, 2005
- HLA expression and immunologic propertiesof differentiated and undifferentiated mesenchymal stem cellsExperimental Hematology, 2003
- Differentiation, cell fusion, and nuclear fusion during ex vivo repair of epithelium by human adult stem cells from bone marrow stromaProceedings of the National Academy of Sciences of the United States of America, 2003
- Pluripotency of mesenchymal stem cells derived from adult marrowNature, 2002