Ion mobility spectrometry coupled with multi-capillary columns for metabolic profiling of human breath
- 15 May 2009
- journal article
- review article
- Published by IOP Publishing in Journal of Breath Research
- Vol. 3 (3), 034001
- https://doi.org/10.1088/1752-7155/3/3/034001
Abstract
Recently, ion mobility spectrometry (IMS) started to be used for direct breath analysis with respect to metabolic profiling, biomarker finding and gas trace analysis. The present review describes the basic operation of an ion mobility spectrometer including the ionization process, humidity effects and sampling procedures. To enhance the resolution, pre-separation by multi-capillary columns (MCCs) is discussed and examples for IMS chromatograms are presented. The focus is to review the analytical method IMS with respect to potential use for direct investigations of humid air in direct breath analysis but not on detailed discussion of results of specific medical application of MCC/IMS or on specific analytes found in exhaled air.Keywords
This publication has 113 references indexed in Scilit:
- Using a nanoelectrospray-differential mobility spectrometer-mass spectrometer system for the analysis of oligosaccharides with solvent selected control over ESI aggregate ion formationJournal of the American Society for Mass Spectrometry, 2007
- Characterizing Electrospray Ionization Using Atmospheric Pressure Ion Mobility SpectrometryAnalytical Chemistry, 2006
- High-Resolution Field Asymmetric Waveform Ion Mobility Spectrometry Using New Planar Geometry AnalyzersAnalytical Chemistry, 2006
- Proton affinity measurements using ion mobility spectrometryThe Journal of Chemical Thermodynamics, 2003
- Studies on gas-phase positive ion—molecule reactions of relevance to ion mobility spectrometry The reactions of 2-methyl-2-propanol (t-butyl alcohol) with protonated water clusters in an ion mobility systemInternational Journal of Mass Spectrometry and Ion Processes, 1998
- High resolution ion mobility measurements for gas phase proteins: correlation between solution phase and gas phase conformationsInternational Journal of Mass Spectrometry and Ion Processes, 1997
- Method for the Collection and Assay of Volatile Organic Compounds in BreathAnalytical Biochemistry, 1997
- Proton transfer reaction mass spectrometry (PTR-MS): propanol in human breathInternational Journal of Mass Spectrometry and Ion Processes, 1996
- Portable hand-held gas chromatography/ion mobility spectrometry deviceAnalytical Chemistry, 1993
- Differentiating between large isomers and derivation of structural information by ion mobility spectrometry / mass spectrometry techniquesInternational Journal of Mass Spectrometry and Ion Processes, 1988