The Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging: methodology and baseline characteristics of 1112 individuals recruited for a longitudinal study of Alzheimer's disease
Top Cited Papers
- 1 August 2009
- journal article
- research article
- Published by Cambridge University Press (CUP) in International Psychogeriatrics
- Vol. 21 (4), 672-687
- https://doi.org/10.1017/s1041610209009405
Abstract
Background: The Australian Imaging, Biomarkers and Lifestyle (AIBL) flagship study of aging aimed to recruit 1000 individuals aged over 60 to assist with prospective research into Alzheimer's disease (AD). This paper describes the recruitment of the cohort and gives information about the study methodology, baseline demography, diagnoses, medical comorbidities, medication use, and cognitive function of the participants.Methods: Volunteers underwent a screening interview, had comprehensive cognitive testing, gave 80 ml of blood, and completed health and lifestyle questionnaires. One quarter of the sample also underwent amyloid PET brain imaging with Pittsburgh compound B (PiB PET) and MRI brain imaging, and a subgroup of 10% had ActiGraph activity monitoring and body composition scanning.Results: A total of 1166 volunteers were recruited, 54 of whom were excluded from further study due to comorbid disorders which could affect cognition or because of withdrawal of consent. Participants with AD (211) had neuropsychological profiles which were consistent with AD, and were more impaired than participants with mild cognitive impairment (133) or healthy controls (768), who performed within expected norms for age on neuropsychological testing. PiB PET scans were performed on 287 participants, 100 had DEXA scans and 91 participated in ActiGraph monitoring.Conclusion: The participants comprising the AIBL cohort represent a group of highly motivated and well-characterized individuals who represent a unique resource for the study of AD. They will be reassessed at 18-month intervals in order to determine the predictive utility of various biomarkers, cognitive parameters and lifestyle factors as indicators of AD, and as predictors of future cognitive decline.Keywords
This publication has 34 references indexed in Scilit:
- The evolution and genetics of cerebral asymmetryPhilosophical Transactions B, 2008
- Patterns of antidepressants prescriptions in a large Italian old populationInternational Journal of Geriatric Psychiatry, 2008
- Global measures: utility in defining and measuring treatment response in dementiaInternational Psychogeriatrics, 2007
- Biological markers as outcome measures for Alzheimer's disease interventions – real problems and future possibilitiesInternational Psychogeriatrics, 2007
- Global prevalence of dementia: a Delphi consensus studyThe Lancet, 2006
- Normative Data on the Boston Naming Test and Two Equivalent 30-Item Short FormsThe Clinical Neuropsychologist, 2000
- The Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE): socio-demographic correlates, reliability, validity and some normsPsychological Medicine, 1989
- Clinical diagnosis of Alzheimer's diseaseNeurology, 1984
- Development and validation of a geriatric depression screening scale: A preliminary reportJournal of Psychiatric Research, 1983
- The Hospital Anxiety and Depression ScaleActa Psychiatrica Scandinavica, 1983