Nested Case–Control Study of Autoimmune Disease in an Asbestos-ExposedPopulation
- 1 August 2006
- journal article
- research article
- Published by Environmental Health Perspectives in Environmental Health Perspectives
- Vol. 114 (8), 1243-1247
- https://doi.org/10.1289/ehp.9203
Abstract
To explore the potential association between asbestos exposure and risk of autoimmune disease, we conducted a case–control study among a cohort of 7,307 current and former residents of Libby, Montana, a community with historical occupational and environmental exposure to asbestos-contaminated vermiculite. Cases were defined as those who reported having one of three systemic autoimmune diseases (SAIDs): systemic lupus erythematosus, scleroderma, or rheumatoid arthritis (RA). Controls were randomly selected at a 3:1 ratio from among the remaining 6,813 screening participants using frequency-matched age and sex groupings. The odds ratios (ORs) and 95% confidence intervals (CIs) for SAIDs among those ≥ 65 years of age who had worked for the vermiculite mining company were 2.14 (95% CI, 0.90–5.10) for all SAIDs and 3.23 (95% CI, 1.31–7.96) for RA. In this age group, exposure to asbestos while in the military was also an independent risk factor, resulting in a tripling in risk. Other measures of occupational exposure to vermiculite indicated 54% and 65% increased risk for SAIDs and RA, respectively. Those who had reported frequent contact with vermiculite through various exposure pathways also demonstrated elevated risk for SAIDs and RA. We found increasing risk estimates for SAIDs with increasing numbers of reported vermiculite exposure pathways (p < 0.001). These preliminary findings support the hypothesis that asbestos exposure is associated with autoimmune disease. Refined measurements of asbestos exposure and SAID status among this cohort will help to further clarify the relationship between these variables.Keywords
This publication has 20 references indexed in Scilit:
- A Review of the Federal Government's Health Activities in Response to Asbestos-Contaminated Ore Found in Libby, MontanaInhalation Toxicology, 2006
- Assessment of Autoimmune Responses Associated with Asbestos Exposure in Libby, Montana, USAEnvironmental Health Perspectives, 2005
- Occupational exposure to crystalline silica and risk of systemic lupus erythematosus: A population‐based, case–control study in the Southeastern United StatesArthritis & Rheumatism, 2002
- Occupational exposure to crystalline silica and autoimmune disease.Environmental Health Perspectives, 1999
- Evidence for the role of environmental agents in the initiation or progression of autoimmune conditions.Environmental Health Perspectives, 1999
- Asbestos and silica-induced changes in human alveolar macrophage phenotype.Environmental Health Perspectives, 1997
- Silica exposure and autoimmune diseasesAmerican Journal of Industrial Medicine, 1995
- Silica-associated Connective Tissue Disease: A Study of 24 CasesMedicine, 1995
- Humoral Immunity Alterations after Environmental Asbestos ExposureRespiration, 1989
- An epidemiological survey of immunological abnormalities in asbestos workersEnvironmental Research, 1980