Effects of desipramine on the antioxidant status in rat tissues at carrageenan-induced paw inflammation
- 27 September 2011
- journal article
- research article
- Published by Wiley in Cell Biochemistry and Function
- Vol. 30 (1), 18-23
- https://doi.org/10.1002/cbf.1812
Abstract
The pathogenesis of many diseases and different pathological conditions, including inflammation, is associated with excess production of reactive oxygen species (ROS). The present study aimed to investigate the effects of the antidepressant desipramine (DES) on carrageenan (CG)-induced inflammation, as well as on the endogenous levels of cell enzyme and non-enzyme antioxidants in rat liver and spleen, 4 and 24 h after CG injection. The intra-plantar CG injection into the right hind paw resulted in a time-dependent increase in the paw volume; the maximum of CG-induced edema peak was in 2–4 h. A single DES dose of 20 mg·kg−1, administered 30 min before CG, had no effect on paw edema, whereas the higher drug dose used (50 mg·kg−1) suppressed the edematous response to CG. The latter drug dose protected CG-induced decrease of glutathione (non-enzyme antioxidant) in the liver; it did not affect CG-unchanged activities of superoxide dismutase, glutathione peroxidase (enzyme antioxidants) and glucose-6-phosphate dehydrogenase (enzyme, important for the activity of glutathione-conjugated antioxidant enzymes) in both liver and spleen. The drug showed an efficient antioxidant capacity in ROS-generating chemical systems; it was higher than that of fluoxetine (another type of antidepressant). The present results suggest that the good antioxidant activity of DES might contribute to its beneficial effects in liver injuries. Copyright © 2011 John Wiley & Sons, Ltd.Keywords
This publication has 38 references indexed in Scilit:
- In-vivo effects of nociceptin and its structural analogue [Orn9] nociceptin on the antioxidant status of rat blood and liver after carrageenan-induced paw inflammationOpen Medicine, 2010
- In vivo effects of N/OFQ(1–13)NH2 and its structural analogue [ORN9]N/OFQ(1–13)NH2 on carrageenan-induced inflammation: rat-paw oedema and antioxidant statusOpen Life Sciences, 2009
- Do Desipramine [10,11-Dihydro-5-[3-(methylamino) propyl]-5H-dibenz[b,f]azepine monohydrochloride] and Fluoxetine [N-Methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]-propan-1-amine] Ameliorate the Extent of Colonic Damage Induced by Acetic Acid in Rats?Journal of Pharmacology and Experimental Therapeutics, 2008
- Desipramine Induces Apoptotic Cell Death through Nonmitochondrial and Mitochondrial Pathways in Different Types of Human Colon Carcinoma CellsPharmacology, 2007
- Anti-inflammatory properties of desipramine and fluoxetineRespiratory Research, 2007
- Analgesic effects of serotonergic, noradrenergic or dual reuptake inhibitors in the carrageenan test in rats: Evidence for synergism between serotonergic and noradrenergic reuptake inhibitionNeuropharmacology, 2006
- Characterization of cytotoxic actions of tricyclic antidepressants on human HT29 colon carcinoma cellsEuropean Journal of Pharmacology, 2006
- Evaluation of antiinflammatory activity of the total flavonoids ofLaggera pterodonta on acute and chronic inflammation modelsPhytotherapy Research, 2006
- The Effect of Local Anesthetics and Amitriptyline on Peroxidation In Vivo in an Inflammatory Rat Model: Preliminary ReportsAnesthesia & Analgesia, 2002
- Effects of chlomipramine and fluoxetine on subcutaneous carrageenin-induced inflammation in the ratInflammation Research, 1995