Global maps of natural hazard occurrence and risk are useful tools for policy makers and international development organizations. The ranking of countries or regions by relative exposure provides a metric for prioritizing strategies for natural hazard mitigation and risk management, and for planning for response and recovery. However, the calculations underlying global natural hazard risk mapping depend on the availability and quality of geophysical and socio-economic data, which are highly variable from region to region, and may impede the application of global rankings to regional decision making. This paper summarizes a recent synthesis of natural hazard occurrence, exposure and loss data—the World Bank's “Hotspots” project—and describes the advantages and difficulties in such an approach. Several suggestions for more highly resolved, regional and sub-national analyses are made.