The ovary: basic biology and clinical implications
Top Cited Papers
Open Access
- 1 April 2010
- journal article
- review article
- Published by American Society for Clinical Investigation in JCI Insight
- Vol. 120 (4), 963-972
- https://doi.org/10.1172/jci41350
Abstract
The classical view of ovarian follicle development is that it is regulated by the hypothalamic-pituitary-ovarian axis, in which gonadotropin-releasing hormone (GnRH) controls the release of the gonadotropic hormones follicle-stimulating hormone (FSH) and luteinizing hormone (LH), and that ovarian steroids exert both negative and positive regulatory effects on GnRH secretion. More recent studies in mice and humans indicate that many other intra-ovarian signaling cascades affect follicular development and gonadotropin action in a stage- and context-specific manner. As we discuss here, mutant mouse models and clinical evidence indicate that some of the most powerful intra-ovarian regulators of follicular development include the TGF-β/SMAD, WNT/FZD/β-catenin, and RAS/ERK1/2 signaling pathways and the FOXO/FOXL2 transcription factors.Keywords
This publication has 129 references indexed in Scilit:
- Loss of inhibin alpha uncouples oocyte-granulosa cell dynamics and disrupts postnatal folliculogenesisDevelopmental Biology, 2009
- The involvement of the Toll-like receptor family in ovulationJournal of Assisted Reproduction and Genetics, 2008
- NOBOX Homeobox Mutation Causes Premature Ovarian FailureAmerican Journal of Human Genetics, 2007
- FoxOs Are Lineage-Restricted Redundant Tumor Suppressors and Regulate Endothelial Cell HomeostasisCell, 2007
- R-spondin1 is essential in sex determination, skin differentiation and malignancyNature Genetics, 2006
- Tissue-Engineered Follicles Produce Live, Fertile OffspringTissue Engineering, 2006
- Follicle-stimulating hormone/cAMP regulation of aromatase gene expression requires β-cateninProceedings of the National Academy of Sciences, 2006
- Oogenesis requires germ cell-specific transcriptional regulators Sohlh1 and Lhx8Proceedings of the National Academy of Sciences, 2006
- FSH signaling pathways in immature granulosa cells that regulate target gene expression: Branching out from protein kinase ACellular Signalling, 2006
- Smad-dependent and Smad-independent pathways in TGF-β family signallingNature, 2003