Converging functional magnetic resonance imaging evidence for a role of the left inferior frontal lobe in semantic retention during language comprehension
- 1 December 2009
- journal article
- research article
- Published by Taylor & Francis Ltd in Cognitive Neuropsychology
- Vol. 26 (8), 685-704
- https://doi.org/10.1080/02643291003665688
Abstract
Increasing evidence supports dissociable short-term memory (STM) capacities for semantic and phonological representations. Cognitive neuropsychological data suggest that damage to the left inferior and middle frontal gyri are associated with deficits of semantic STM, while damage to inferior parietal areas is associated with deficits of phonological STM. Patients identified as having semantic STM deficits are also impaired on a number of language comprehension and production paradigms. We used one such comprehension task derived from cognitive neuropsychological data to test predictions with functional magnetic resonance imaging (fMRI) using healthy participants. Using a task that required participants to make semantic anomaly judgements, we found significantly greater activation in areas of the left inferior frontal and middle frontal gyri for phrases that required maintenance of multiple words for eventual integration with a subsequent noun or verb. These data are consistent with our previous patient studies (Hanten & Martin, 2000; R. C. Martin & He, 2004; R. C. Martin & Romani, 1994 Martin, R. C. and Romani, C. 1994. Verbal working memory and sentence comprehension: A multiple-components view. Neuropsychology, 8: 506–523. [Crossref] [Google Scholar] ) that suggest that semantic STM is associated with the left inferior and middle frontal gyri and that deficits of semantic STM have particular consequences for comprehension tasks that require maintenance of several word meanings in unintegrated form.Keywords
This publication has 35 references indexed in Scilit:
- Confidence intervals in within-subject designs: A simpler solution to Loftus and Masson's methodThe Quantitative Methods for Psychology, 2005
- Acute conduction aphasia: An analysis of 20 casesBrain and Language, 2003
- Semantic Processing in the Left Inferior Prefrontal Cortex: A Combined Functional Magnetic Resonance Imaging and Transcranial Magnetic Stimulation StudyJournal of Cognitive Neuroscience, 2003
- Models of Functional Organization of the Lateral Prefrontal Cortex in Verbal Working Memory: Evidence in Favor of the Process ModelJournal of Cognitive Neuroscience, 2002
- Contribution of lexico-semantic processes to verbal short-term memory tasks: A PET activation studyMemory, 2001
- A Comment on the Functional Localization of the Phonological Storage Subsystem of Working MemoryBrain and Cognition, 1999
- Mapping of semantic, phonological, and orthographic verbal working memory in normal adults with functional magnetic resonance imaging.Neuropsychology, 1999
- AFNI: Software for Analysis and Visualization of Functional Magnetic Resonance NeuroimagesComputers and Biomedical Research, 1996
- Dissociation of Storage and Rehearsal in Verbal Working Memory: Evidence From Positron Emission TomographyPsychological Science, 1996
- The Uses of Short-Term Memory: A Case StudyThe Quarterly Journal of Experimental Psychology Section A, 1986