False‐Positive Galactomannan PlateliaAspergillusTest Results for Patients Receiving Piperacillin‐Tazobactam
Open Access
- 15 March 2004
- journal article
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 38 (6), 913-916
- https://doi.org/10.1086/382224
Abstract
At the bone marrow transplantation center of the San Martino Hospital (Genoa), we observed an increase in the rate of patients with positive Platelia Aspergillus (PA; Bio-Rad) test results, from 10% (38 of 386 patients) in the period from January 1999 through January 2003 to 36% (21 of 59 patients) in the period from February 2003 through May 2003. Positivity was significantly (P < .001) associated with the administration of piperacillin-tazobactam (PT) (17 [74%] of 23 patients who received PT had positive results vs. 4 [11%] of 36 who did not receive PT). Multivariate analysis found administration of PT (χ2 = 34.7; P < .001) and underlying disease (χ2 = 21.14; P < .001) to be associated with PA positivity. Of 15 PT batches tested, 12 had positive PA test results.Keywords
This publication has 13 references indexed in Scilit:
- Use of Circulating Galactomannan Screening for Early Diagnosis of Invasive Aspergillosis in Allogeneic Stem Cell Transplant RecipientsThe Journal of Infectious Diseases, 2002
- Voriconazole versus Amphotericin B for Primary Therapy of Invasive AspergillosisNew England Journal of Medicine, 2002
- Transient aspergillus antigenaemia: think of milkThe Lancet, 2002
- AspergillusGalactomannan Detection in the Diagnosis of Invasive Aspergillosis in Cancer PatientsJournal of Clinical Oncology, 2002
- Aspergillus Galactomannan Antigen in the Cerebrospinal Fluid of Bone Marrow Transplant Recipients with Probable Cerebral AspergillosisJournal of Clinical Microbiology, 2002
- Defining Opportunistic Invasive Fungal Infections in Immunocompromised Patients with Cancer and Hematopoietic Stem Cell Transplants: An International ConsensusClinical Infectious Diseases, 2002
- Value of antigen detection using an enzyme immunoassay in the diagnosis and prediction of invasive aspergillosis in two adult and pediatric hematology units during a 4-year prospective studyCancer, 2001
- Comparison of an enzyme immunoassay and a latex agglutination system for the diagnosis of invasive aspergillosis in bone marrow transplant recipientsBone Marrow Transplantation, 1998
- Prospective sandwich enzyme-linked immunosorbent assay for serum galactomannan: early predictive value and clinical use in invasive aspergillosisThe Pediatric Infectious Disease Journal, 1996
- Cyclophosphamide Induces False-Positive Results in Detection of Aspergillus Antigen in UrineChest, 1994