Evaluation and review of ways to differentiate sources of ethanol in postmortem blood
- 1 November 2020
- journal article
- review article
- Published by Springer Science and Business Media LLC in International journal of legal medicine
- Vol. 134 (6), 2081-2093
- https://doi.org/10.1007/s00414-020-02415-9
Abstract
Accurate determination of a person's blood alcohol concentration (BAC) is an important task in forensic toxicology laboratories because of the existence of statutory limits for driving a motor vehicle and workplace alcohol testing regulations. However, making a correct interpretation of the BAC determined in postmortem (PM) specimens is complicated, owing to the possibility that ethanol was produced in the body after death by the action of various micro-organisms (e.g., Candida species) and fermentation processes. This article reviews various ways to establish the source of ethanol in PM blood, including collection and analysis of alternative specimens (e.g., bile, vitreous humor (VH), and bladder urine), the identification of non-oxidative metabolites of ethanol, ethyl glucuronide (EtG) and ethyl sulfate (EtS), the urinary metabolites of serotonin (5-HTOL/5-HIAA), and identification ofn-propanol andn-butanol in blood, which are known putrefaction products. Practical utility of the various biomarkers including specificity and stability is discussed.Keywords
This publication has 109 references indexed in Scilit:
- Collection of biological samples in forensic toxicologyToxicology Mechanisms and Methods, 2010
- Biomarkers to disclose recent intake of alcohol: potential of 5-hydroxytryptophol glucuronide testing using new direct UPLC-tandem MS and ELISA methodsAlcohol and Alcoholism, 2007
- COMPARISON OF SERUM FATTY ACID ETHYL ESTERS AND URINARY 5-HYDROXYTRYPTOPHOL AS BIOCHEMICAL MARKERS OF RECENT ETHANOL CONSUMPTIONAlcohol and Alcoholism, 2005
- Insights into the Origin of Postmortem EthanolInternational Journal of Toxicology, 2005
- Mass Spectrometric Identification of Ethyl Sulfate as an Ethanol Metabolite in HumansClinical Chemistry, 2004
- Ethyl glucuronide—the direct ethanol metabolite on the threshold from science to routine useAddiction, 2003
- Postmortem Diffusion of Alcohol from the StomachAmerican Journal of Forensic Medicine & Pathology, 1995
- Possible Sources of Ethanol Ante‐ and Post‐mortem: its Relationship to the Biochemistry and Microbiology of DecompositionJournal of Applied Bacteriology, 1978
- PENETRATION RATE OF ALCOHOL INTO THE VITREOUS HUMOR STUDIED WITH A NEW IN VIVO TECHNIQUEActa Ophthalmologica, 1971
- Glucose Content of Normal UrineBMJ, 1965