Incidence of allergic contact sensitization in central Chinese subjects with chronic urticaria
Open Access
- 1 April 2016
- journal article
- Published by FapUNIFESP (SciELO) in Anais Brasileiros de Dermatologia
- Vol. 91 (2), 168-172
- https://doi.org/10.1590/abd1806-4841.20164606
Abstract
Chronic urticaria (CU) can be provoked by a wide variety of causes. Some studies suggest contact sensitization may play a role in the disease. To investigate the incidence and distribution characteristics of allergic contact sensitization in central Chinese subjects with CU, and assess contact allergen avoidance measures in managing CU. Patch tests were performed, following the recommended standard procedure, with 20 selected allergens, in line with the European baseline series. All subjects with positive results were prescribed appropriate avoidance measures for the sensitizing substances, while subjects with negative results served as the control group. CU severity was assessed daily from week1 to week4 and for each subject, applying the Urticaria Activity Score. 42.9% (233/543) of subjects with CU showed positive reactions to one or more contact allergen(s). Potassium dichromate, benzene mix and carba mix were more common in male patients, while nickel sulfate was more frequent in females. The positive rates for different allergens varied with age and occupation. The median (interquartile range) severity scores at week 1 were 20 (14-21) and 15 (14-27) for the allergen avoidance group and control group, respectively (P>0.05); and 12 (7-15) and 14 (12-17) at week 4 (P<0.001). The incidence of allergic contact sensitization in CU patients was high, and appropriate contact allergen avoidance measures benefitted CU management. Contact allergens may play a role in the pathogenic mechanism of CU and patch tests are an option for CU patients.Keywords
This publication has 17 references indexed in Scilit:
- Methods report on the development of the 2013 revision and update of the EAACI/GA2LEN/EDF/WAO guideline for the definition, classification, diagnosis, and management of urticariaAllergy, 2014
- The diagnosis and management of acute and chronic urticaria: 2014 updateJournal of Allergy and Clinical Immunology, 2014
- Impact of Contact Sensitization in Chronic Spontaneous UrticariaThe American Journal of the Medical Sciences, 2011
- Use of patch testing for identifying allergen causing chronic urticariaIndian Journal of Dermatology, Venereology and Leprology, 2008
- Contact allergy in male construction workers in Sao Paulo, Brazil, 2000–2005Contact Dermatitis, 2007
- Role of contact sensitization in chronic urticariaJournal of the American Academy of Dermatology, 2007
- A new tool to evaluate the impact of chronic urticaria on quality of life: chronic urticaria quality of life questionnaire (CU‐Q2oL)Allergy, 2005
- Chronic idiopathic urticaria: Comparison of the clinical features of patients with and without anti-FcϵRI or anti-IgE autoantibodiesJournal of the American Academy of Dermatology, 1999
- Prevalence of Helicobacter pylori–Associated Gastritis in Chronic UrticariaInternational Archives of Allergy and Immunology, 1998
- Etiologic aspects of chronic urticariaInternational Journal of Dermatology, 1998