Ruthenium-Catalyzed C–H/N–O Bond Functionalization: Green Isoquinolone Syntheses in Water
Top Cited Papers
- 11 November 2011
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 13 (24), 6548-6551
- https://doi.org/10.1021/ol202861k
Abstract
Ruthenium-catalyzed isoquinolone syntheses with ample scope were accomplished through carboxylate assistance in environmentally benign water as a reaction medium. The high chemoselectivity of the ruthenium(II) carboxylate complex also set the stage for the direct use of free hydroxamic acids for annulations of alkynes.Keywords
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