Hypoxia‐inducible factor‐1 as a therapeutic target in cancer
- 26 February 2013
- journal article
- review article
- Published by Wiley in Journal of Gastroenterology and Hepatology
- Vol. 28 (3), 401-405
- https://doi.org/10.1111/jgh.12038
Abstract
Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that immortalizes tumors by inducing key genes in cancer biology, including angiogenesis, glycolysis, invasion, and metastasis. Overexpression of HIF-1α is thus associated with resistance to cancer chemotherapy and increased patient mortality in several cancer phenotypes. In the present review, we summarize the role of intratumoral hypoxia and bioactive lipids in enhancing HIF-1 activity, critically discussing the potential for HIF-1α inhibitors in cancer chemotherapy. Considering preclinical studies, HIF-1 inhibitors appear to have antitumor effects and thus represent a novel therapeutic strategy.Keywords
This publication has 40 references indexed in Scilit:
- RETRACTED ARTICLE: HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungsOncogene, 2011
- 12-Lipoxygenase and the regulation of hypoxia-inducible factor in prostate cancer cellsExperimental Cell Research, 2010
- Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularizationProceedings of the National Academy of Sciences of the United States of America, 2009
- Hypoxia-inducible factor-1α and -2α are expressed in most rectal cancers but only hypoxia-inducible factor-1α is associated with prognosisBritish Journal of Cancer, 2009
- Hypoxia-specific stabilization of HIF-1alpha by human papillomavirusesVirology, 2009
- Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cellsProceedings of the National Academy of Sciences of the United States of America, 2009
- Digoxin and other cardiac glycosides inhibit HIF-1α synthesis and block tumor growthProceedings of the National Academy of Sciences of the United States of America, 2008
- Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase PathwayMolecular Cell, 2008
- Hypoxia-inducible factor-1α expression in the gastric carcinogenesis sequence and its prognostic role in gastric and gastro-oesophageal adenocarcinomasBritish Journal of Cancer, 2006
- How many drug targets are there?Nature Reviews Drug Discovery, 2006