CT prediction of histological grade of hypervascular hepatocellular carcinoma: utility of the portal phase
- 17 October 2012
- journal article
- Published by Springer Science and Business Media LLC in Japanese Journal of Radiology
- Vol. 31 (2), 89-98
- https://doi.org/10.1007/s11604-012-0149-5
Abstract
To elucidate whether the attenuation of hypervascular hepatocellular carcinoma (HCC) on the portal phase of dynamic CT is correlated with histological grade. This study group consisted of 66 patients with 74 surgically resected, hypervascular HCCs. On a preoperative dynamic study with a 64-multidetector row CT, the portal phase was scanned 60 s after injecting the contrast agent following the pre-contrast image and hepatic arterial phase. The tumor attenuation of each HCC on the portal phase was categorized into high, iso-, or low, and was compared with the predominant histological grade using Mann–Whitney’s U test. Twenty-nine, 29, and 16 HCCs showed high, iso-, and low attenuation on the portal phase, respectively. Tumors were classified into three well- (w-), 58 moderately (m-), or 13 poorly (p-) differentiated HCCs. The tumor attenuation of p-HCC on the portal phase was significantly lower than those of w-HCC and m-HCC (p < 0.05 and p < 0.00001). The tumor attenuation on the portal phase may help when diagnosing the histological grade of hypervascular HCC. p-HCC are considered to show a faster contrast washout than w-HCC and m-HCC.Keywords
This publication has 20 references indexed in Scilit:
- Enhancement pattern analysis of hypervascular hepatocellular carcinoma on dynamic MR imaging with histopathological correlation: Validity of portal phase imaging for predicting tumor gradeEuropean Journal of Radiology, 2012
- Multiphasic MDCT Enhancement Pattern of Hepatocellular Carcinoma Smaller Than 3 cm in Diameter: Tumor Size and Cellular DifferentiationAmerican Journal of Roentgenology, 2009
- Multidetector CT portal venography in evaluation of portosystemic collateral vesselsJournal of Medical Imaging and Radiation Oncology, 2008
- Arterial Blood Supply of Hepatocellular Carcinoma and Histologic Grading: Radiologic-Pathologic CorrelationAmerican Journal of Roentgenology, 2008
- Imaging well-differentiated hepatocellular carcinoma with dynamic triple-phase helical computed tomographyThe British Journal of Radiology, 2006
- Triple-Phase MDCT of Hepatocellular CarcinomaAmerican Journal of Roentgenology, 2004
- Characterization of Hepatocellular Carcinomas with Triphasic Ct and Correlation with Histopathologic FindingsActa Radiologica, 2003
- Hepatocellular CarcinomaJournal of Clinical Gastroenterology, 2002
- Vascular invasion and histopathologic grading determine outcome after liver transplantation for hepatocellular carcinoma in cirrhosisJournal of Hepatology, 2001
- The History of Poiseuille's LawAnnual Review of Fluid Mechanics, 1993