Circuit Topology Analysis of Polymer Folding Reactions
Open Access
- 12 May 2020
- journal article
- research article
- Published by American Chemical Society (ACS) in ACS Central Science
- Vol. 6 (6), 839-847
- https://doi.org/10.1021/acscentsci.0c00308
Abstract
Circuit topology is emerging as a versatile measure to classify the internal structures of folded linear polymers such as proteins and nucleic acids. The topology framework can be applied to a wide range of problems, most notably molecular folding reactions that are central to biology and molecular engineering. In this Outlook, we discuss the state-of-the art of the technology and elaborate on the opportunities and challenges that lie ahead.Keywords
Funding Information
- Muscular Dystrophy Association (MDA628071)
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