Reactive species and DNA damage in chronic inflammation: reconciling chemical mechanisms and biological fates
Open Access
- 2 December 2010
- journal article
- review article
- Published by Wiley in International Journal of Cancer
- Vol. 128 (9), 1999-2009
- https://doi.org/10.1002/ijc.25815
Abstract
Chronic inflammation has long been recognized as a risk factor for many human cancers. One mechanistic link between inflammation and cancer involves the generation of nitric oxide, superoxide and other reactive oxygen and nitrogen species by macrophages and neutrophils that infiltrate sites of inflammation. Although pathologically high levels of these reactive species cause damage to biological molecules, including DNA, nitric oxide at lower levels plays important physiological roles in cell signaling and apoptosis. This raises the question of inflammation‐induced imbalances in physiological and pathological pathways mediated by chemical mediators of inflammation. At pathological levels, the damage sustained by nucleic acids represents the full spectrum of chemistries and likely plays an important role in carcinogenesis. This suggests that DNA damage products could serve as biomarkers of inflammation and oxidative stress in clinically accessible compartments such as blood and urine. However, recent studies of the biotransformation of DNA damage products before excretion point to a weakness in our understanding of the biological fates of the DNA lesions and thus to a limitation in the use of DNA lesions as biomarkers. This review will address these and other issues surrounding inflammation‐mediated DNA damage on the road to cancer.This publication has 151 references indexed in Scilit:
- Oxidative stress, inflammation, and cancer: How are they linked?Free Radical Biology & Medicine, 2010
- Thioredoxin and thioredoxin reductase: Current research with special reference to human diseaseBiochemical and Biophysical Research Communications, 2010
- A review of human carcinogens—Part B: biological agentsPublished by Elsevier BV ,2009
- The reemergence of nitric oxide and cancerNitric Oxide, 2008
- DNA repair of oxidative DNA damage in human carcinogenesis: Potential application for cancer risk assessment and preventionCancer Letters, 2008
- The chemical biology of nitric oxide: Implications in cellular signalingFree Radical Biology & Medicine, 2008
- Interstrand DNA Cross-Links Induced by α,β-Unsaturated Aldehydes Derived from Lipid Peroxidation and Environmental SourcesAccounts of Chemical Research, 2008
- Mutagenic potential of DNA–peptide crosslinks mediated by acrolein-derived DNA adductsMutation research. Reviews in mutation research, 2008
- Inflammation and cancer: An ancient link with novel potentialsInternational Journal of Cancer, 2007
- The Pecking Order of Free Radicals and Antioxidants: Lipid Peroxidation, α-Tocopherol, and AscorbateArchives of Biochemistry and Biophysics, 1993