Analgesia Mediated by a Direct Spinal Action of Narcotics
- 25 June 1976
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 192 (4246), 1357-1358
- https://doi.org/10.1126/science.1273597
Abstract
Narcotic analgetics administered directly into the spinal subarachnoid space of the rat via a chronically inserted catheter produce a potent analgesia that can be antagonized by naloxone. The narcotics, acting only at the spinal level, changed cord function to block not only spinal reflexes but also the operant response to painful stimuli.Keywords
This publication has 13 references indexed in Scilit:
- Systematic examination in the rat of brain sites sensitive to the direct application of morphine: Observation of differential effects within the periaqueductal grayBrain Research, 1976
- Autoradiographic localization of the opiate receptor in rat brainLife Sciences, 1975
- Effects of brain lesions on the antinociceptive properties of morphine in ratsClinical and Experimental Pharmacology and Physiology, 1975
- Localization of the antinociceptive action of morphine in primate brainPharmacology Biochemistry and Behavior, 1975
- Effects of Morphine and Naloxone on Dorsal Horn Neurones in the CatCanadian Journal of Physiology and Pharmacology, 1974
- Sites of morphine induced analgesia in the primate brain: relation to pain pathwaysBrain Research, 1974
- Lamina-specific Suppression of Dorsal-horn Unit Activity by Morphine SulfateAnesthesiology, 1974
- Morphine Action at Central Nervous System Sites in Rat: Analgesia or Hyperalgesia Depending on Site and DoseScience, 1973
- On the central sites for the antinociceptive action of morphine and fentanylNeuropharmacology, 1970
- Pain Mechanisms: A New TheoryScience, 1965