Indonesian Medicinal Plants. XXV. Cancer Cell Invasion Inhibitory Effects of Chemical Constituents in the Parasitic Plant Scurrula atropurpurea (Loranthaceae).

Abstract

Six fatty acids (1—6), two xanthines (7, 8), two flavonol glycosides (9, 10), one monoterpene glucoside (11), one lignan glycoside (12), and four flavanes (13—16) were clarified by a bioassay-guided separation as chemical constituents of Scurrula atropurpurea (Loranthaceae), a parasitic plant of the tea plant Thea sinensis (Theaceae). Among these constituents, it was found that the alkynic fatty acid octadeca-8,10,12-triynoic acid (6) exhibits a more potent inhibitory effect on cancer cell invasion in vitro than flavanes [(+)-catechin (13), (−)-epicatechin (14), (−)-epicatechin-3-O-gallate (15) and (−)-epigallocatechin-3-O-gallate (16)].