Analysis of Tissues Following Mesenchymal Stromal Cell Therapy in Humans Indicates Limited Long-Term Engraftment and No Ectopic Tissue Formation
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Open Access
- 2 May 2012
- journal article
- research article
- Published by Oxford University Press (OUP) in The International Journal of Cell Cloning
- Vol. 30 (7), 1575-1578
- https://doi.org/10.1002/stem.1118
Abstract
Mesenchymal stromal cells (MSCs) are explored as a novel treatment for a variety of medical conditions. Their fate after infusion is unclear, and long‐term safety regarding malignant transformation and ectopic tissue formation has not been addressed in patients. We examined autopsy material from 18 patients who had received human leukocyte antigen (HLA)‐mismatched MSCs, and 108 tissue samples from 15 patients were examined by PCR. No signs of ectopic tissue formation or malignant tumors of MSC‐donor origin were found on macroscopic or histological examination. MSC donor DNA was detected in one or several tissues including lungs, lymph nodes, and intestine in eight patients at levels from 1/100 to 2012;30:1575–1578Keywords
Funding Information
- Swedish Cancer Foundation (110315)
- Children's Cancer Foundation (08/071)
- Swedish Research Council (K2011-??X-20742-04-6)
- Tobias Foundation, VINNOVA (2010-00501)
- Stockholm City Council (20110152)
- Cancer Society in Stockholm
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