Sox17 inhibits hepatocellular carcinoma progression by downregulation of KIF14 expression
- 10 August 2014
- journal article
- Published by Springer Science and Business Media LLC in Tumor Biology
- Vol. 35 (11), 11199-11207
- https://doi.org/10.1007/s13277-014-2398-7
Abstract
Sox17, an antagonist of canonical Wnt/β-catenin signaling, inhibits several malignant carcinogenesis and progression. However, little is known about Sox17 in hepatocellular carcinoma (HCC). Here, we found that Sox17 is downregulated in HCC tissue. Furthermore, Sox17 inhibits cell proliferation and migration in HCC. KIF14, a member of kinesin superfamily protein (KIFs), is an oncogene in a variety of malignant tumors including HCC. We demonstrated that Sox17 is negatively related to KIF14 expression in HCC tissue and Sox17 inhibits HCC cell proliferation and migration by transcriptional downregulation of KIF14 expression. Our results may provide a strategy for blocking HCC carcinogenesis and progression.Keywords
This publication has 39 references indexed in Scilit:
- Sox17 promotes tumor angiogenesis and destabilizes tumor vessels in miceJCI Insight, 2012
- KIF14 negatively regulates Rap1a–Radil signaling during breast cancer progressionThe Journal of cell biology, 2012
- Sox17 regulates proliferation and cell cycle during gastric cancer progressionCancer Letters, 2011
- Induction and Down-regulation of Sox17 and Its Possible Roles During the Course of Gastrointestinal TumorigenesisGastroenterology, 2009
- Sox17 Dependence Distinguishes the Transcriptional Regulation of Fetal from Adult Hematopoietic Stem CellsCell, 2007
- KIF14 Messenger RNA Expression Is Independently Prognostic for Outcome in Lung CancerClinical Cancer Research, 2007
- Strategies for Safer Liver Surgery and Partial Liver TransplantationThe New England Journal of Medicine, 2007
- Sox17 is essential for the specification of cardiac mesoderm in embryonic stem cellsProceedings of the National Academy of Sciences of the United States of America, 2007
- Molecular pathogenesis of human hepatocellular carcinomaNature Genetics, 2002
- Molecular pathogenesis of human hepatocellular carcinomaAdvances in Cancer Research, 2002