Magnesium deficiency induces an hyperalgesia reversed by the NMDA receptor antagonist MK801
- 1 April 1997
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in NeuroReport
- Vol. 8 (6), 1383-1386
- https://doi.org/10.1097/00001756-199704140-00013
Abstract
THE aim of this study was to determine the changes of the nociceptive thresholds in response to an acute mechanical stimulus (paw pressure) in magnesium (Mg)-deficient rats, and the involvement of the NMDA receptor in these changes. Changes in vocalization thresholds was determined after 7 days of feeding with a Mg-depleted diet. Compared with the control group, Mg-deficient rats showed a significant decrease in the vocalization thresholds (−35.8 ± 2.5%, pKeywords
This publication has 15 references indexed in Scilit:
- Modulation by magnesium of the affinity of NMDA receptors for glycine in murine hippocampal neurones.The Journal of Physiology, 1995
- The utility of excitatory amino acid (EAA) antagonists as analgesic agents. I. Comparison of the antinociceptive activity of various classes of EAA antagonists in mechanical, thermal and chemical nociceptive testsPain, 1994
- Reduction in joint swelling and hyperalgesia following post-treatment with a non-NMDA glutamate receptor antagonistPain, 1994
- Enhanced NMDA conductance can account for epileptiform activity induced by low Mg2+ in the rat hippocampal slice.The Journal of Physiology, 1994
- (+)-HA 966, a partial agonist at the glycine site coupled to NMDA receptors, blocks formalin-induced pain in miceEuropean Journal of Pharmacology, 1993
- μ- and κ-opioid receptor agonists produce peripheral inhibition of neurogenic plasma extravasation in rat skinEuropean Journal of Pharmacology, 1993
- Quantitative analysis of substance P and calcitonin gene-related peptide immunohistochemical staining in the dorsal horn of neuropathic MK-801-treated ratsBrain Research, 1993
- The Effects of Morphine, MK-801, an NMDA Antagonist, and CP-96,345, an NK1 Antagonist, on the Hyperesthesia Evoked by Carageenan Injection in the Rat PawAnesthesiology, 1993
- Ethical guidelines for investigations of experimental pain in conscious animalsPain, 1983
- Substance P as neurogenic mediator of antidromic vasodilation and neurogenic plasma extravasationNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1979